New aplysiatoxin derivatives from the Okinawan cyanobacterium Moorea producens |
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| Authors: | Hiroshi Nagai Minami Watanabe Shingo Sato Mioko Kawaguchi Yue-Yun Xiao Kazutaka Hayashi Ryuichi Watanabe Hajime Uchida Masayuki Satake |
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| Institution: | 1. Department of Ocean Sciences, Tokyo University of Marine Science and Technology, Tokyo 108-8477, Japan;2. National Research Institute of Fisheries Science, Japan Fisheries Research and Education Agency, Yokohama, Kanagawa 236-8648, Japan;3. Department of Chemistry, The University of Tokyo, Tokyo 113-0033, Japan |
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| Abstract: | The marine cyanobacterium Moorea producens is a rich source of diverse compounds that possess a variety of biological activities. In the present study, eight new aplysiatoxin derivatives, namely 6, 8–13, and 15, along with aplysiatoxin (1), debromoaplysiatoxin (2), 3-methoxyaplysiatoxin (3), anhydroaplysiatoxin (4), anhydrodebromoaplysiatoxin (5), oscillatoxin B2 (7), and 30-methyloscillatoxin D (14) were isolated and identified from the Okinawan M. producens. In cytotoxicity and diatom growth inhibition tests, the fifteen compounds tested (1–15) showed moderate or no activity at a concentration of 10?μg/mL. |
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| Keywords: | Aplysiatoxin Cyanobactrium Structure elucidation Cytotoxicity |
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