Hydrophobic polymers modification of mesoporous silica with large pore size for drug release |
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Authors: | Shenmin Zhu Di Zhang Na Yang |
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Institution: | (1) State Key Lab of Metal Matrix Composites, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai, 200030, P.R. China;(2) Key Lab of Molecular Engineering of Polymers, Fudan University, Ministry of Education, Shanghai, P.R. China |
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Abstract: | Mesostructure cellular foam (MCF) materials were modified with hydrophobic polyisoprene (PI) through free radical polymerization
in the pores network, and the resulting materials (MCF-PI) were investigated as matrices for drug storage. The successful
synthesis of PI inside MCF was characterized by Fourier transform infrared (FT-IR), hydrogen nuclear magnetic resonance (1H NMR), X-ray diffraction patterns (XRD) and nitrogen adsorption/desorption measurements. It was interesting to find the resultant
system held a relatively large pore size (19.5 nm) and pore volume (1.02 cm3 g−1), which would benefit for drug storage. Ibuprofen (IBU) and vancomycin were selected as model drugs and loaded onto unmodified
MCF and modified MCF (MCF-PI). The adsorption capacities of these model drugs on MCF-PI were observed increase as compared
to that of on pure MCF, due to the trap effects induced by polyisoprene chains inside the pores. The delivery system of MCF-PI
was found to be more favorable for the adsorption of IBU (31 wt%, IBU/silica), possibly attributing to the hydrophobic interaction
between IBU and PI formed on the internal surface of MCF matrix. The release of drug through the porous network was investigated
by measuring uptake and release of IBU. |
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Keywords: | Mesoporous silica Hydrophobic polymers Surface modification Pore size IBU Nanomedicine |
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