A novel vapor phase process for aromatic ketone synthesis |
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Authors: | Itsuo Furuoya |
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Affiliation: | (1) Technology Development Laboratories, Takeda Chemical Industries, Ltd., 17 85, Juso Honmachi, 2 Chome, Yodogawa ku, Osaka, 532 8686, Japan |
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Abstract: | The vapor phase catalytic reaction between aromatic carboxylic acid and acetic acid was investigated. Many metal oxides catalyzed the reaction between 2 methylbenzoic acid (OTA) and acetic acid (AA) to produce 2 methylacetophenone (OMA), and weakly acidic oxides such as Th, U, Ce, and La oxide exhibited higher yield of OMA. The OMA yield depended on the catalyst support. SiO2, Al2O3, TiO2, and ZrO2 with a surface area of less than 200 m2 g–1 appeared to be suitable as industrial catalyst supports. CeO2 on Al2O3was chosen as an industrial catalyst for the synthesis of OMA because of higher productivity, longer catalyst life, and lifting of legal restrictions on catalyst handling. This catalyst system can also be applied to the syntheses of acetophenone, nitroacetophenone, and chloroacetophenone. |
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Keywords: | aromatic ketone 2 /content/m1274j4038230616/xxlarge8208.gif" alt=" dash" align=" MIDDLE" BORDER=" 0" >methylacetophenone weakly acidic oxide CeO2/Al2O3 |
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