Thin-layer differential pulse voltammetric determination of chlorpromazine in biological fluids |
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| Authors: | Tafeedah B Jarbawi William R Heineman Gaston J Patriache |
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| Institution: | Department of Chemistry, University of Cincinnati, Cincinnati, OH 45221 U.S.A.;Institut de Pharmacie, Université Libre de Bruxelles, Campus Plaine B.P. 205/1, 1050 BruxellesBelgium |
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| Abstract: | The combination of a thin-layer electrochemical cell with differential pulse voltammetry can be used to determine chlorpromazine in plasma and urine. The thin-layer cell (23 μl capacity) has a wax-impregnated graphite electrode. Direct determination of chlorpromazine in urine gave a linear calibration curve for the range 4.8 × 10-3–2.4 × 10-4 M with 97% recovery. No interference from glutethimide, dextropropoxyphene, meprobamate, diazepam, and methaqualone-HCl was detected. Direct measurement of chlorpromazine in plasma gave a linear calibration curve for the range 2.4 × 10-5–4.8 × 10-4 M with 89% recovery. The procedure for plasma and urine requires only 2 min per determination. Detection levels are below that required for monitoring therapeutic levels of chlorpromazine in urine. |
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