| 光动力疗法用糖基光敏剂的研究进展 |
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| 引用本文： | 张沛,张淑芬.光动力疗法用糖基光敏剂的研究进展[J].有机化学,2010,30(6). |
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| 作者姓名： | 张沛 张淑芬 |
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| 作者单位： | 大连理工大学化工学院,大连,116012 |
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| 基金项目： | 国家杰出青年基金，长江学者和创新团队发展计划 |
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| 摘 要： | 作为光动力疗法中至关重要的决定性因素,光敏剂的研究受到越来越多的重视.而糖基的引入,可以大大提高光敏剂母体的膜透过性和特异吸收性.从糖基光敏剂的母体结构、糖基光敏剂分子的构效关系、糖基的作用机理以及糖基光敏剂的药物动力学和代谢产物这四个方面对近年来糖基光敏剂的研究现状进行了综述,对其发展趋势进行了展望.
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| 关 键 词： | 光动力疗法 光敏剂 糖基 |
Development of Glucoconjugated Photosensitizers in Photodynamic Therapy |
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| Zhang Pei,Zhang Shufen.Development of Glucoconjugated Photosensitizers in Photodynamic Therapy[J].Chinese Journal of Organic Chemistry,2010,30(6). |
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| Authors: | Zhang Pei Zhang Shufen |
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| Institution: | Zhang,Pei Zhang,Shufen*(School of Chemical Engineering,Dalian University of Technology,Dalian 116012) |
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| Abstract: | Photosensitizers have attracted increasing attention as a critical role in photodynamic therapy(PDT).The membrane penetrability and the selective absorption of photosensitizers could be improved by linking carbohydrate.The research of glucoconjugated photosensitizers including the parent structure of glucoconjugated photosensitizers,the structure-activity relationships of glucoconjugated photosensitizers,the mechanisms of sugar radical in the compounds,the pharmacokinetics and metabolic product of glucoconj... |
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| Keywords: | photodynamic therapy photosensitizer carbohydrate |
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