New palladium(II) complexes with pyrazole ligands |
| |
Authors: | Carolina V Barra Fillipe V Rocha Adelino V G Netto B Shimura Regina C G Frem Antonio E Mauro Iracilda Z Carlos Sandra R Ananias Marcela B Quilles |
| |
Institution: | 1.Departamento de Química Geral e Inorganica, Instituto de Química de Araraquara,UNESP–Univ Estadual Paulista,Araraquara,Brazil;2.Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas de Araraquara,UNESP–Univ Estadual Paulista,Araraquara,Brazil |
| |
Abstract: | The pyrazole ligand 3,5-dimethyl-4-iodopyrazole (HdmIPz) has been used to obtain a series of palladium(II) complexes (1–4) of the type PdX2(HdmIPz)2] {X = Cl− (1); Br− (2); I− (3); SCN− (4)}. All compounds have been isolated, purified, and characterized by means of elemental analysis, IR spectroscopy, 1H and 13C{1H}-NMR experiments, differential thermal analysis (DTA), and thermogravimetry (TG). The TG/DTA curves showed that the compounds
released ligands in the temperature range 137–605 °C, yielding metallic palladium as final residue. The complexes and the
ligand together with cisplatin have been tested in vitro by MTT assay for their cytotoxicity against two murine cancer cell
lines: mammary adenocarcinoma (LM3) and lung adenocarcinoma (LP07). |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|