A novel route to the vinyl sulfide nine-membered macrocycle moiety of Griseoviridin |
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| Authors: | Marcantoni E Massaccesi M Petrini M Bartoli G Bellucci M C Bosco M Sambri L |
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| Affiliation: | Dipartimento di Scienze Chimiche, Camerino (MC), Italy. enricom@camserv.unicam.it |
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| Abstract: | The synthetic potentialities of cerium(III) chloride are demonstrated by the synthesis of a nine-membered ring heterocycle component of Griseoviridin (3) in optically active form. The key step involves the stereospecific formation of the alpha-carbalkoxy alkenyl sulfide moiety using a combination system of cerium(III) chloride heptahydrate and sodium iodide. |
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