米非司酮治疗围绝经期功血的临床效果

目的探讨米非司酮在围绝经期子宫出血应用中的临床效果。方法选取2013年1月至2014年12月期间在天津市武清区中医医院采用米非司酮治疗的围绝经期功能性子宫出血患者36例作为研究对象,给予2个月连续服用米非司酮12.5 mg/d,对治疗前后的子宫体积大小变化情况、血清激素水平变化及不良反应进行比较。结果在应用米非司酮治疗后所有患者均出现闭经,未发现有明显的不良反应,且肝肾功能基本正常。治疗后子宫内膜的厚度明显小于治疗前子宫内膜厚度,差异有统计学意义(P0.05);治疗前后患者的子宫体积大小变化差异无统计学意义(P0.05);患者治疗前后FSH、LH、E2、P等指标改善显著(P0.05)。结论应用米非司酮治疗围绝经期功血,使用方便,疗效肯定,副反应少,在临床值得推广应用。

The Clinical Effect of Mifepristone in the Treatment of Perimenopausal Dysfunctional Uterine Bleeding

Objective To investigate the clinical effect of mifepristone in perimenopausal uterine bleeding applications. Methods From January 2013 to December 2014 in our hospital, 36 cases of patients with dysfunctional uterine bleeding treated with mifepristone were treated as the research object, and 2 months after treatment, the changes of the volume of the uterus, serum hormone levels and adverse reactions were compared. Results All patients appeared after mifepristone treatment of amenorrhea, found no significant adverse reactions, and basic liver and kidney function was normal. After treatment, endometrial thickness was significantly smaller than the thickness of the endometrium before treatment, the difference was statistically significant ( P <0. 05 ); Uterine volume changes in the size difference before and after treatment in patients with no significant difference ( P >0. 05 ); Indicators improved FSH, LH, E2, P and other significant before and after treatment ( P < 0. 05 ). Conclusion Mifepristone treatment of perimenopausal uterine bleeding, easy to use, more effective, less side effects, should be widely applied in clinical.