Optically active heteroaromatic compounds IX. Preparation,absolute configuration and optical purity of some chiral 3-alkylindoles |
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Authors: | Rita Menicagli Corrado Malanga Luciano Lardicci |
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Abstract: | The Fischer and Brunner reactions as well as the Grignard alkylation of isatin have been used to prepare (S)-3-sec-butyl- and (S)-3-(2-methylbutyl)indoles, respectively, starting from (S)-1-chloro-2-methylbutane. The stereospecificity of the synthetic sequences followed has been investigated and the stereochemical relationships of the title compounds have been established. |
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