| 新型六氢山酮素拼接异噁唑双螺环氧化吲哚类化合物的合成 |
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| 引用本文： | 汪军鑫,巩艺,周英,刘雄利,邓国栋. 新型六氢山酮素拼接异噁唑双螺环氧化吲哚类化合物的合成[J]. 合成化学, 2020, 28(2): 118-122. DOI: 10.15952/j.cnki.cjsc.1005-1511.19198 |
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| 作者姓名： | 汪军鑫 巩艺 周英 刘雄利 邓国栋 |
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| 作者单位： | 1. 贵州大学 贵州省药食同源植物资源开发工程技术研究中心，贵州 贵阳 550025; 2. 贵州中医药大学 药学院，贵州 贵阳 550025 |
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| 摘 要： | 以色酮-氧化吲哚合成子1与氧化吲哚3-烯烃硝基异噁唑2，在催化剂DABCO催化下，在氯仿中发生双Michael加成环化反应，合成了7个未见文献报道的六氢山酮素拼接异噁唑双螺环氧化吲哚类化合物3a~3g，产率78%~92%，dr值10/1~15/1,其结构经1H NMR, 13C NMR和HR-MS（ESI-TOF）表征。
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| 关 键 词： | 氧化吲哚-色酮合成子 异噁唑 双Michael加成环化反应 六氢山酮素 合成 |
| 收稿时间： | 2019-05-19 |
Synthesis of Novel Hexahydroxanthone-fused Isoxazole-based Bispirooxindoles |
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| WANG Jun-xin,GONG Yi,ZHOU Ying,LIU Xiong-li,DENG Guo-dong. Synthesis of Novel Hexahydroxanthone-fused Isoxazole-based Bispirooxindoles[J]. Chinese Journal of Synthetic Chemistry, 2020, 28(2): 118-122. DOI: 10.15952/j.cnki.cjsc.1005-1511.19198 |
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| Authors: | WANG Jun-xin GONG Yi ZHOU Ying LIU Xiong-li DENG Guo-dong |
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| Affiliation: | 1. Guizhou Medicine Edicine Edible Plant Resources Research and Developmant Center, Guizhou University, Guiyang 550025, China; 2. College of Pharmaceutical Sciences, Guizhou University of Chinese Medicine, Guiyang 550025, China |
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| Abstract: | Seven new hexahydroxanthone-fused isoxazole-based bispirooxindoles(3 a^3 g)were synthesized via an DABCO-catalyzed dual Michael cycloaddition of cHR-omone-oxindole synthons 1 with 5-isatylidenyl-isoxazoles 2 at room temperature in CHCl3 for 3 d. The yields and dr of 3 a^3 g were 78%~92% and 10/1~15/1, respectively. The structures of products were characterized by ^1H NMR, ^13C NMR and HR-MS(ESI-TOF). |
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| Keywords: | cHR-omone-oxindole synthon isoxazole dual Michael cycloaddition reaction hexahydroxanthone synthesis |
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