| Abstract: | The treatment of 16α-bromo-17-ketosteroids and 2-bromo-3-ketosteroids with thiourea in dimethylformamide give the corresponding 2′-formamidothiazolosteroids. The resulting 2′-formamidothiazoles were identical with those obtained in a similar reaction from 17β-bromo-16α,17α-oxidoandrostane with thiourea. Hydrolysis of the 2′-formamido-thiazolosteroids led to the corresponding 2′-aminothiazoles, which also resulted from the interaction of bromoketones and thiourea in isopropanol. The title compounds prepared were substantiated by examination of infrared, ultraviolet, mass and nuclear magnetic resonance spectra. |
