咪唑并[1,2-a]吡啶化合物的无溶剂合成及其抗氧化性能

无溶剂条件下，2-氨基吡啶、芳香醛和异氰基乙酸乙酯发生Groebke-Blackburn-Bienaymé三组分反应，高效合成了6个咪唑并1,2-a]吡啶化合物，产率89%~97%，其结构经¹H NMR, ¹³C NMR和HR-MS（ESI）确证。并通过抑制HO·和还原型谷胱甘肽自由基(GS·)引发的DNA氧化反应体系，对化合物的抗氧化活性进行了检测。结果表明：在抑制HO·引发的DNA氧化反应体系中，6个化合物相对空白硫代巴比妥酸活性物质吸光度百分数（TBARS百分数）可达32.2%~72.1%；在抑制GS·引发的DNA氧化反应体系中，6个化合物的TBARS百分数可达34.8%~81.3%。

Solvent Free Synthesis and Antioxidant Properties of Imidazo[1,2-a] pyridine Compounds

With 2-aminopyridine, the substituted aromatic aldehydes, and ethyl 2-isocyanoacetate as reactants, six imidazo1,2-a]pyridine compounds were synthesized via Groebke-Blackburn-Bienaymé three-component-reaction in the absence of solvents, and the yield were 89%~97%. The structures were confirmed by 1HNMR, 13CNMR, and HR-MS(ESI). Antioxidant abilities of the obtained compounds were evaluated by inhibiting Cu2+/glutathione(GSH)-and HO·-induced oxidation of DNA. The results showed that the TBARS percentages of six compounds were 32.2%~72.1% in inhibiting HO·-induced oxidation of DNA. The TBARS percentages of six compounds were 34.8%~81.3% in inhibiting GS·-induced oxidation of DNA.