|
|||||
|
|
The identification of tricyclic neuroleptics and sulphonamides by high-performance thin-layer chromatography |
|
| Authors: | A. Li Wan Po W. J. Irwin |
| Abstract: | Circular high-performance thin-layer chromatography (HPTLC) has been used to differentiate a series of twelve tricyclic neuroleptics, using both normal phase and reverse phase procedures. The use of normal phase systems also allows the resolution of geometric isomers of chlorprothixene, clopenthixol and flupenthixol. Thirteen sulphonamides and Trirnethoprim may also be distinguished using HPTLC. |
| Keywords: | Thin-layer chromatography, HPTLC Tricyclic Neuroleptics, Sulphonamides Circulare technique in adsorption and reversed phase mode 12 samples simultaneous within less than 2 minutes Precise and highly reproducible Rf and k-data for structure determination Advantages shown not only for drug analysis in forensic and toxicological labs |