l-Selective dipeptide synthesis using novel thermophilic enzyme from Clostridium sp. |
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| Institution: | 1. Organic Division I, Indian Institute of Chemical Technology, Hyderabad 500 007, India;2. Department of Microbiology, Osmania University, Hyderabad 500 007, India;1. Technology Development Centre, Custom Pharmaceutical Services, Dr. Reddy’s Laboratories Ltd, Hyderabad 500049, India;2. Department of Chemistry, Krishna University, Machilipatnam, Andhra Pradesh, India;1. School of Physical Sciences, Jawaharlal Nehru University, New Delhi 110 067, India;2. Department of Chemistry, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh 495 009, India |
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| Abstract: | A novel, inexpensive, thermophilic protease-type enzyme isolated from Clostridium thermohydrosulfuricum was used for dipeptide synthesis. The enzyme showed broad substrate selectivity and enantioselectivity towards l-amino acids in peptide bond formation. |
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