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Enantioselective synthesis of (S)-salmeterol via asymmetric reduction of azidoketone by Pichia angusta |
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| Affiliation: | 1. Laboratoire Vibration Acoustique (LVA), INSA de Lyon, 25 Avenue Jean Capelle, 69621 Villeurbanne Cedex, France;2. AREVA NDE-Solutions, 4 Rue Thomas Dumorey, 71100 Chalon-sur-Saône, France;3. EDF R&D SINETICS, 1 Avenue du Général de Gaulle, 92141 Clamart Cedex, France |
| Abstract: | An efficient enantioselective route to (S)-salmeterol involving asymmetric reduction of an azidoketone intermediate to an azido alcohol by Pichia angusta is described. |
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