Efficient resolution of naproxen by inclusion crystallization with N-octyl-glucamine and structure characterization of the inclusion complex期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Efficient resolution of naproxen by inclusion crystallization with N-octyl-glucamine and structure characterization of the inclusion complex

Affiliation:	1. University of Queensland Centre of Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia;2. ICON Cancer Centre, Department of Pharmacy, Brisbane, Queensland, Australia;3. Department of Intensive Care Medicine, Gold Coast University Hospital, Gold Coast, Queensland, Australia;4. Department of Chemical Pathology, Pathology Queensland, Royal Brisbane and Women''s Hospital, Brisbane, Queensland, Australia;5. University of Queensland, School of Medicine, Brisbane, Australia;6. Department of Intensive Care Medicine, Royal Brisbane and Women''s Hospital, Brisbane, Queensland, Australia;7. Department of Pharmacy, Royal Brisbane and Women''s Hospital, Brisbane, Queensland, Australia;8. Centre for Translational Anti-infective Pharmacodynamics, School of Pharmacy, The University of Queensland, Brisbane, Queensland, Australia;9. Division of Anaesthesiology Critical Care Emergency and Pain Medicine, Nîmes University Hospital, University of Montpellier, Nîmes, France

Abstract:	(S)-(+)-Naproxen was directly resolved from the racemate with high enantiopurity (>95% e.e.) by inclusion crystallization using N-octyl-d-(−)-glucamine as the chiral host. The crystal structure of the inclusion complex was determined.

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