Preparation of planar chiral amino phenols based on the [2.2]paracyclophane backbone |
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| Institution: | 1. Institut für Organische Chemie der Rheinisch-Westfälischen Technischen Hochschule Aachen, Professor-Pirlet-Straße 1, D-52074 Aachen, Germany;2. Kekulé-Institut für Organische Chemie und Biochemie der Rheinischen Friedrich-Wilhelms-Universität Bonn, Gerhard-Domagk-Straße 1, D-53121 Bonn, Germany;1. Department of Drug Technology and Pharmaceutical Biotechnology, Medical University of Warsaw, Banacha 1 Str., 02-097 Warszawa, Poland;2. Faculty of Pharmacy, Medical University of Warsaw, Banacha 1 Str., 02-097 Warszawa, Poland;1. The College of Chemistry and Molecular Engineering, The Key Lab of Chemical Biology and Organic Chemistry of Henan Province, The Key Lab of Advanced Nano-information Materials of Zhengzhou, Zhengzhou University, Zhengzhou 450001, Henan, China;2. Department of Chemistry, Zhengzhou Normal University, Zhengzhou 450044, Henan, China |
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| Abstract: | The synthesis of various planar and central chiral secondary and tertiary amino phenols based on the 2.2]paracyclophane backbone is described. Planar chiral tertiary amino phenols are prepared by reductive amination of 5-formyl-4-hydroxy2.2]paracyclophane (FHPC) with secondary amines. The reduction of imine and ketimine precursors, as well as the 1,2-addition to these compounds is also described. |
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