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Enantiopure vic-amino alcohols and vic-diamines from (1R,2S)-1,2-dihydroxy-1,2-dihydronaphthalene
Institution:1. Dipartimento di Chimica Organica e Industriale, Universita’ degli Studi di Milano, Milan Italy;2. Dipartimento di Scienze dell’ Ambiente e del Territorio, Milano-Bicocca, Milan, Italy;1. University of Rostock, Institute of Chemistry, Albert-Einstein-Strasse 3a, D-18059 Rostock, Germany;2. Leibniz Institute for Catalysis at the University of Rostock, Albert-Einstein-Str. 29a, D-18059 Rostock, Germany;3. Department of Chemical Sciences, University of Naples ‘Federico II’, I-80126—Via Cinthia 4, Napoli, Italy;1. Department of Pharmacology of Chinese Materia Medica, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China;2. Department of Natural Medicinal Chemistry, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China;3. School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, China
Abstract:(1S,2S)-2-Hydroxy-1-amino-1,2,3,4-tetrahydronaphthalene, (1R,2R)-1-hydroxy-2-amino-1,2,3,4-tetrahydronaphthalene, (1S,2R)-1,2-diamino-1,2,3,4-tetrahydronaphthalene, (2R,3S)-2-hydroxy-3-amino-1,2,3,4-tetrahydronaphthalene and (2S,3S)-2,3-diammino-1,2,3,4-tetrahydronaphthalene have been synthesized from (1R,2S)-1,2-dihydroxy-1,2-dihydronaphthalene. The latter was obtained, using a protocol reported in a previous paper, from naphthalene using an Escherichia coli recombinant strain containing the naphthalene dioxygenase gene cloned from Pseudomonas fluorescens N3.
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