Enantioselective copper-catalyzed conjugate addition using chiral diaminocarbene ligands |
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| Institution: | 1. School of Physical Sciences, University of Kent, Canterbury, Kent, CT2 7NH, UK;2. College of Artificial Intelligence, Nankai University, Tianjin, 300071, China;3. Department of Computer Science, University of Haifa, Mount Carmel, Haifa, Israel;4. School of Engineering and Digital Arts, University of Kent, Canterbury Kent, CT2 7NT, UK;5. School of Physics and Optoelectronics Engineering, Shandong University of Technology, Zibo, 255049, China |
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| Abstract: | Chiral diaminocarbene ligands, generated by in-situ deprotonation of the corresponding chiral imidazolinium salts, are shown to be efficient ligands in the asymmetric copper-catalyzed 1,4-conjugate addition of diethylzinc to enones, allowing enantiomeric excesses of up to 51% to be achieved. |
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