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Synthesis of optically active functionalised cyclic ketimines and their application in enantioselective catalysis
Affiliation:1. Department of Chemistry, Carnegie Mellon University, Pittsburgh, PA, USA;2. Center for Nucleic Acids Science & Technology, Carnegie Mellon University, Pittsburgh, PA, USA;3. Faculty of Chemistry, University of Warsaw, Pasteura 1, Warsaw, Poland;1. Department of Neuropsychopharmacology, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan;2. International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki, Japan
Abstract:The synthesis of enantiomerically pure cyclic ketimines attached to moieties containing additional donor atoms is described. The resulting optically active chelating ligands are tested in the rhodium-catalysed enantioselective hydrosilylation of acetophenone with respect to their inductive potential.
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