Radical fluoroarylation in radiochemical synthesis |
| |
| Authors: | Christina Hultsch,Hans-Jü rgen Wester |
| |
| Affiliation: | a Nuklearmedizinische Klinik und Poliklinik, Klinikum Rechts der Isar, Technische Universität München, Germany
b Organische Chemie 1, Technische Universität München, Lichtenbergstr. 4, D-85747 Garching, Germany |
| |
| Abstract: | In this study, we report on the radical [18F]fluoroarylation of different olefins using 4-[18F]fluorobenzenediazonium ions to provide a new route to radiopharmaceuticals containing a deactivated, 4-[18F]fluoro substituted phenyl group. This new methodology was shown to be well suited for the synthesis of 18F-labelled stilbenes. Stilbene 7 is now accessible within 80 min in 30-45% overall radiochemical yield starting from [18F]fluoride. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
