Chiral N-phosphonyl imine chemistry: new reagents and their applications for asymmetric reactions |
| |
| Authors: | Adiseshu Kattuboina |
| |
| Institution: | Department of Chemistry and Biochemistry, Texas Tech University Lubbock, TX 79409-1061, USA |
| |
| Abstract: | Novel chiral N-phosphonyl imines 2 have been designed and synthesized using chiral N-phosphoramide 1. These N-phosphonyl imines have been successfully utilized for asymmetric aza-Darzens reaction and asymmetric aza-Henry reaction. The C2-symmetric chiral auxiliary tolerates oxidation, is not sensitive to racemization and can be recycled for large scale synthesis. |
| |
| Keywords: | Phosphoramide N-Phosphonyl imines Aziridine aza-Darzens reaction aza-Henry reaction C2-Symmetric diamine |
| 本文献已被 ScienceDirect 等数据库收录！ |
