Gold-catalyzed heterocycle synthesis using homopropargylic ethers as latent electrophiles |
| |
Authors: | Jung Hyung Hoon Floreancig Paul E |
| |
Institution: | Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA. |
| |
Abstract: | reaction: see text] Homopropargylic ethers with pendent nucleophiles, when subjected to Au catalysts in aqueous solvent, provide heterocyclic ketones. The reactions are efficient, tolerant of functionality and ambient atmosphere, and operationally simple. Diastereoselectivity can be predicted on the basis of product thermodynamics. This process demonstrates the viability of homopropargylic ethers to serve as latent electrophiles that can be unraveled under highly selective conditions to promote heterocycle formation through nucleophilic additions to alpha,beta-unsaturated ketones. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|