预防性抗生素用于胆囊切除术对术后感染性并发症的预防作用

目的观察预防性抗生素用于胆囊切除术对术后感染性并发症的预防作用。方法选取2013年5月—2015年9月普宁市人民医院肿瘤外科收治的106例胆囊疾病患者为研究对象,按随机数字表法分为两组各53例,对照组行腹腔镜胆囊切除术治疗,观察组另行胆囊切除术及预防性抗生素治疗,观察两组围术期指标[手术时间、手术切口、术中出血量、住院时间],同时观察两组术后感染性并发症发生情况。结果观察组手术时间、手术切口、出血量、住院时间治疗指标均较对照组小,只有住院时间两组间差异显著(P0.05),其它差异均无统计学意义(P0.05)。且观察组术后感染性并发症总发生率1.89%较对照组11.32%低,但不具有统计学意义(P0.05)。结论胆囊切除术中合理使用预防性抗生素可显著减小患者住院时间,但对患者术后感染性并发症发生无显著预防作用。由于本次样本量较少,需进一步研究。

Effects of Prophylactic Antibiotics Applied in Cholecystectomy in the Prevention of Postoperative Infectious Complications

Objective To observe the effects of prophylactic antibiotics applied in cholecystectomy in the prevention of postoperative infectious complications. Methods 106 cases of patients with gallbladder diseases who were treated in the department of oncological surgery in our hospital between May 2013 and September 2015 were selected as the study objects and were randomized into two groups by random number table method, 53 cases in each. The control group was treated with laparoscopic cholecystectomy while the observation group was treated with cholecystectomy and prophylactic antibiotics. The perioperative indexes ( operation time, incision, intraoperative bleeding volume, hospitalization time) of the two groups were observed. The occurrence of postoperative infectious complications in the two groups was also observed. Results The operation time, incision, bleeding volume and hospitalization time of the observation group were less than those of the control group and there only was significant difference in hospitalization time between the two groups ( P <0. 05 ) . There was no significant difference in other indexes ( P>0. 05 ) . The incidence rate of postoperative infectious complications in the observation group (1. 89%) was lower than that in the control group (11. 32%) (P>0. 05). Conclusion The rational use of prophylactic antibiotics in cholecystectomy can significantly shorten the hospitalization time but it has no significant preventive effect on postoperative infectious complications. Because of the small sample size, further study can be done.