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Expedient synthesis of 4-O-methylhonokiol via Suzuki-Miyaura cross-coupling |
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| Authors: | Jae-Hwan KwakYoung Ae Cho Jae-Yong JangSeung-Yong Seo Heesoon LeeJin Tae Hong Sang-Bae HanKiho Lee Young-Shin Kwak Jae-Kyung Jung |
| Institution: | a College of Pharmacy and Medical Research Center (MRC), Chungbuk National University, Cheongju 361-763, Republic of Korea b Korea Research Institute of Bioscience and Biotechnology, Ochang 363-883, Republic of Korea c College of Pharmacy, Woosuk University, Wanju 565-701, Republic of Korea d College of Pharmacy, Korea University, Chochiwon 339-700, Republic of Korea |
| Abstract: | Concise and practical synthesis of 4-O-methylhonokiol was achieved in 34% overall yield. The key features of our synthesis include chemoselective ortho-mono bromination of phenol as well as biaryl formation via Suzuki-Miyaura cross-coupling, in which bromophenol was reacted with potassium aryltrifluoroborate using Pd(OAc)2 and RuPhos under microwave conditions. |
| Keywords: | Neolignan 4-O-Methylhonokiol Suzuki-Miyaura cross-coupling Potassium aryltrifluoroborate |
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