Conformational study of N-substituted 8-azabicyclo[3.2.1]octan-3-ones |
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Authors: | M. S. Arias E. Galvez M. L. Izquierdo C. Burgos |
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Affiliation: | Departamento de Química Orgánica, Universidad de Alcalá de Henares, Madrid Spain |
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Abstract: | N-Substituted 8-azabicyclo[3.2.1]octan-3-ones have been studied by 1H and 13C NMR spectroscopy. In CDCl3 solutions, these ketones display the same preferred conformation. The pyrrolidine and piperidone rings adopt a flattened N-8 envelope and distorted chair conformation, puckered at N-8 and flattened at C-3, respectively, with the N-substituent in axial position with respect to the piperidone ring. |
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