Genetic analysis of posterior medial barrel subfield (PMBSF) size in somatosensory cortex (SI) in recombinant inbred strains of mice |
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Authors: | Taha A Jan Lu Lu Cheng-Xiang Li Robert W Williams Robert S Waters |
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Institution: | (1) Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, 38163 Memphis, Tennessee, USA |
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Abstract: | Background Quantitative trait locus (QTL) mapping is an important tool for identifying potential candidate genes linked to complex traits.
QTL mapping has been used to identify genes associated with cytoarchitecture, cell number, brain size, and brain volume. Previously,
QTL mapping was utilized to examine variation of barrel field size in the somatosensory cortex in a limited number of recombinant
inbred (RI) strains of mice. In order to further elucidate the underlying natural variation in mouse primary somatosensory
cortex, we measured the size of the posterior medial barrel subfield (PMBSF), associated with the representation of the large
mystacial vibrissae, in an expanded sample set that included 42 BXD RI strains, two parental strains (C57BL/6J and DBA/2J),
and one F1 strain (B6D2F1). Cytochrome oxidase labeling was used to visualize barrels within the PMBSF. |
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