High temperature normal phase liquid chromatography of aromatic hydrocarbons on bare zirconia |
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Authors: | Paproski Richard E Liang Chen Lucy Charles A |
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Affiliation: | Department of Chemistry, Gunning/Lemieux Chemistry Centre, University of Alberta, Edmonton, AB, Canada T6G 2G2. |
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Abstract: | The normal phase HPLC behavior of a bare zirconia column was studied at temperatures up to 200 °C using a hexane mobile phase. The use of elevated column temperatures significantly decreased the retention of twenty five aromatic model compounds according to the van't Hoff equation (>30-fold decrease for some compounds). Large improvements in peak shape, efficiency (>2.2-fold), aromatic group-type selectivity, and column re-equilibration times (>5-fold) were obtained at elevated temperatures. The thermal decomposition of two polar nitrogen compounds (indole and carbazole) was observed in a hexane/dichloromethane mobile phase at temperatures greater than 100 °C. The first order decomposition of carbazole was studied in further detail. |
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Keywords: | Zirconia Normal phase High temperature high performance liquid chromatography van’t Hoff plot Column re-equilibration On-column decomposition |
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