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Instrumental Requirements for Non-Invasive Blood Glucose Measurement Using NIR Spectroscopy |
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| Authors: | Hidenobu Arimoto Masatoshi Tarumi Yukio Yamada |
| Institution: | (1) Institute of Human Science and Biomedical Engineering, National Institute of Advanced, Industrial Science and Technology, AIST Tsukuba East, Tsukuba, Ibaraki 305-8564, Japan;(2) Nikkiso Co. Ltd., 498-1 Sizutani, Haibara, Sizuoka 421-0496, Japan;(3) Department of Mechanical Engineering and Intelligent Systems, University of Electro-Communications, 1-5-1 Chofugaoka, Chofu, Tokyo 182-8585, Japan |
| Abstract: | The magnitude of spectral change in blood glucose measurements with diffuse reflectance spectroscopy is investigated. Spectral change is estimated by simulation of light propagation in skin tissue and measurements of absorbance spectra of aqueous glucose solution. Required sensitivity of spectrophotometers for monitoring change in the blood glucose concentration as small as 10 mg/dL has been obtained using the estimated change in the absorbance spectrum and mean pathlength of light in tissue. |
| Keywords: | blood glucose measurement non-invasive measurement Monte Carlo simulation NIR spectroscopy scattering |
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