Modification of biologically active amides and amines with fluorine-containing heterocycles 7. Fluorine-containing heterocyclic derivatives of the acetazolamide |
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| Authors: | V B Sokolov A Yu Aksinenko |
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| Institution: | 1. Institute of Physiologically Active Substances, Russian Academy of Sciences, 1 Severnyi proezd, 142432, Chernogolovka, Moscow Region, Russian Federation
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| Abstract: | An approach is proposed to modification of a medical product acetazolamide (N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide) by interaction of 2-(5-acetylamino-1,3,4-thiadiazole-2-yl)sulfonyl imine methyl trifluoropyruvate, which is in-situ generated from acetazolamide, with 1,3-binucleophiles: 6-aminouracils, 6-aminothiouracils, and N-substituted ureas, to yield heterocyclic compounds with the CF3 substituent in the nitrogen-containing mono- or bicycle. |
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