An antimicrobial diketopiperazine alkaloid and co-metabolites from an endophytic strain of Gliocladium isolated from Strychnos cf. toxifera |
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| Authors: | Koolen Hector Henrique Ferreira Soares Elzalina Ribeiro da Silva Felipe Moura Araújo Lima de Souza Antonia Queiroz de Medeiros Lívia Soman Filho Edson Rodrigues de Almeida Richardson Alves Ribeiro Ismael Alexandre do Ó Pessoa Cláudia de Morais Manoel Odorico da Costa Patrícia Marçal de Souza Afonso Duarte Leão |
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| Institution: | a Departamento de Química , Universidade Federal do Amazonas , Av. Gal. Rodrigo Otávio, 3000 Mail Box 69077-000 , Manaus , Amazonas , Brazil. |
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| Abstract: | From an endophytic strain of Gliocladium sp. isolated from the Amazonian plant Strychnos cf. toxifera, we obtained the diketopiperazine alkaloid cyclo-(glycyl-L-tyrosyl)-4,4-dimethylallyl ether (1), the steroids ergosterol (2), ergosterol peroxide (3), cerevisterol (4) and the citric acid (5). The AcOEt extract of the fermented broth by Gliocladium sp. showed potent activity against the cancer cell lines MDA-MB435 (human breast cancer cells), HCT-8 (human colorectal cancer cells) and SF-295 (human glioblastoma cancer cells). Compound 1 exhibited a strong antimicrobial activity against Micrococcus luteus at a concentration of 43.4?μM. |
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