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Zinc-catalyzed silylation of terminal alkynes. |
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| Authors: | Ronald J Rahaim Jared T Shaw |
| Institution: | Broad Institute of Harvard and MIT Program in Chemical Biology, 7 Cambridge Center, Cambridge, MA 02142, USA. |
| Abstract: | A rapid and high-yielding silylation of terminal alkynes employing TMSOTf and catalytic quantities of Zn(OTf)2 has been developed. The reaction works well for a variety of substrates including reactive esters. Fifteen examples with yields of >90% are reported. |
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