An efficient synthesis of enamides from ketones |
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| Authors: | Zhao Hang Vandenbossche Charles P Koenig Stefan G Singh Surendra P Bakale Roger P |
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| Affiliation: | Chemical Process Research and Development, Sepracor Inc., 84 Waterford Drive, Marlborough, Massachusetts 01752, USA. |
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| Abstract: | A new synthesis of enamides from ketones is disclosed that involves a phosphine-mediated reductive acylation of oximes. The resulting enamides are isolated in good yields (up to 89%) and excellent purity, permitting a subsequent hydrogenation to access enantiopure acetamides at catalyst loadings practical for large-scale applications. |
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