Rapid Optimization of Reaction Conditions Based on Comprehensive Reaction Analysis Using a Continuous Flow Microwave Reactor |
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Authors: | Pter Vmosi Keiya Matsuo Tsuguya Masuda Kohei Sato Tetsuo Narumi Kazuhiro Takeda Nobuyuki Mase |
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Institution: | Péter Vámosi,Keiya Matsuo,Tsuguya Masuda,Kohei Sato,Tetsuo Narumi,Kazuhiro Takeda,Nobuyuki Mase |
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Abstract: | Generally, the flow method has the advantage of a precise control over the reaction parameters and a facile modification of the reaction conditions, while a continuous flow microwave reactor allows for the quick optimization of reaction conditions owing to the rapid uniform heating. In this study, we developed a “9+4+1 method” to optimize reaction conditions based on comprehensive reaction analysis using a flow microwave reactor. The proposed method is expected to contribute to the synthesis of various fine and bulk chemicals by reducing cost and wastage, and by conserving time. |
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Keywords: | Acylation design of experiments flow synthesis microwave chemistry optimization |
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