| 四甲基吡嗪多元醇及其乙酸酯的合成 |
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| 引用本文： | 秦凯,李伟,崔小兵. 四甲基吡嗪多元醇及其乙酸酯的合成[J]. 合成化学, 2010, 18(2) |
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| 作者姓名： | 秦凯 李伟 崔小兵 |
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| 作者单位： | 南京中医药大学,药学院,江苏,南京,210029 |
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| 基金项目： | 江苏省自然科学基金，南京中医药大学科技创新风险基金 |
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| 摘 要： | 四甲基吡嗪经溴代和酯化反应得到2,3,5-三乙酰氧甲基-6-甲基吡嗪(4)和2,3,5,6-四乙酰氧甲基吡嗪(5);4和5分别经水解得2,3,5-三羟甲基-6-甲基吡嗪和2,3,5,6-四羟甲基吡嗪。其结构经UV,1H NMR,13C NMR,IR和MS表征。
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| 关 键 词： | 四甲基吡嗪 5-三乙酰氧甲基-6-甲基吡嗪 6-四乙酰氧甲基吡嗪 5-三羟甲基-6-甲基吡嗪 6-四羟甲基吡嗪 合成 |
Synthesis of Polyols of Tetramethylpyrazine and Their Acetates |
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| QIN Kai,LI Wei,CUI Xiao-bing. Synthesis of Polyols of Tetramethylpyrazine and Their Acetates[J]. Chinese Journal of Synthetic Chemistry, 2010, 18(2) |
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| Authors: | QIN Kai LI Wei CUI Xiao-bing |
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| Abstract: | 2,3,5-triacetoxymethyl-6-methylpyrazine and 2,3,5,6-tetracetoxymethylpyrazine were synthesized from tetramethylpyrazine by bromination and esterification, then were hydrolyzed into 2,3,5-trihydroxymethyl-6-methylpyrazine and 2,3,5,6-tetrahydroxymethylpyrazine. The structures were confirmed by UV, ~1H NMR, ~(13)C NMR, IR and MS. |
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| Keywords: | 2 3 2 3 5 2 3 2 3 5 tetramethylpyrazine 2,3,5-triacetoxymethyl-6-methylpyrazine 2,3,5,6-tetracetoxymethylpyrazine 2,3,5-trihydroxymethyl-6-methylpyrazine 2,3,5,6-tetrahydroxymethylpyrazine synthesis |
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