取代苯基吡唑类化合物的合成及其除草活性

以1′-(4-氯-2-氟-5-甲基苯基)-4′,4′,4′-三氟-1,3-丁二酮为原料,合成了一系列具有取代苯基吡唑结构的新化合物.化合物结构经¹HNMR,IR,CIMS和元素分析确认.初步生物活性测试表明,所合成的化合物对阔叶杂草具有较高的活性.

Synthesis and Herbicidal Activity of Substituted Phenyl Pyrazole Derivatives

Herbicides inhibiting protoporphyrinogen oxidase are one of the most important class of herbicides. Targeting the porphyrin pathway, these herbicides show high activity and low toxicity, and have been a hot-point of novel pesticides research. A series of novel substituted phenylpyrazole derivatives were prepared from 1′-(4-chloro-2-fluoro-5-methylphenyl)-4′,4′,4′-trifluoro-1,3-dibutanone via a ring closure reaction, methylation, chlorination, oxidization reaction and so on. The conditions of key steps were discussed. Their structures were confirmed by 1HNMR, IR, CIMS and elemental analysis. Preliminary bioassay shows that these compounds have good herbicidal activity to latifoliate weeds, and their activity is better in soil treatment than in stem and leaf treatment.