Facile access to γ-aminothiols from 1,3-thiazines via a microwave-assisted three-component reaction |
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| Authors: | Flavie Peudru Remi Legay Jean-François Lohier Vincent Reboul Mihaela Gulea |
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| Institution: | Laboratoire de Chimie Moléculaire et Thioorganique, UMR CNRS 6507, INC3M, FR 3038, ENSICAEN, Université de Caen Basse Normandie, 6, Bd. Maréchal Juin, 14050 Caen, France |
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| Abstract: | A new efficient and general synthetic methodology to access γ-aminothiols was investigated and developed. 1,3-Thiazines were used as convenient precursors and were prepared by a fast microwave-assisted three-component reaction (3CR) of thioamides, aldehydes, and alkenes. The transformation of thiazines into aminothiols was achieved via a thiazinium salt hydrolysis, in three very facile steps. |
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