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Green synthesis and antioxidant activity of new PEGylated ferulic acids
Authors:François Nicks  Aurore Richel  Gaetan Richard  Pascal Laurent  Bernard Wathelet  Jean-Paul Wathelet  Michel Paquot
Affiliation:1. Unit of Biological and Industrial Chemistry, University of Liege-Gembloux Agro-Bio Tech, Passage des Déportés 2, B-5030 Gembloux, Belgium;2. Unit of General and Organic Chemistry, University of Liege-Gembloux Agro-Bio Tech, Passage des Déportés 2, B-5030 Gembloux, Belgium
Abstract:PEGylation of ferulic acid is described through a green esterification process involving poly(ethylene glycol) (PEG) with three different average molecular weights (200, 400 and 1000 g/mol) as both reactive and solvent. Esterification with PEG400 and PEG1000 leads to original compounds soluble in all proportions in water. These new compounds display an antioxidant activity similar to that of ferulic acid.
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