Synthesis of pyrrolophenanthridone alkaloid kalbretorine from indolecarboxylic acids via hypervalent iodine(III) mediated halodecarboxylation and reduction |
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Authors: | Yasuyoshi Miki Hideaki Umemoto Masashi Dohshita Hiromi Hamamoto |
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Institution: | School of Pharmaceutical Sciences, Kinki University, 3-4-1 Kowakae, Higashi-Osaka 577-8502, Japan |
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Abstract: | The treatment of 8,9,10-trimethoxy-7H-pyrrolo3,2,1-de]phenanthridine-4,5-dicarboxylic acid with phenyliodine diacetate and potassium iodide in tetrahydrofuran gave the corresponding 4,5-diiodo derivative, which was converted to kalbretorine via reduction, demethylation, followed by alkylation. |
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