Naphthalimide-based fluorescent off/on probes for the detection of thiols |
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| Authors: | Wei Sun Wenhua Li Jing Li Jian Zhang Lupei Du Minyong Li |
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| Affiliation: | 1. Department of Medicinal Chemistry, Key Laboratory of Chemical Biology of Natural Products (MOE), School of Pharmacy, Shandong University, Jinan, Shandong 250012, China;2. Institute of Immunopharmacology & Immunotherapy, School of Pharmacy, Shandong University, Jinan, Shandong 250012, China |
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| Abstract: | Herein, we report the design and synthesis of two naphthalimide-based fluorescent probes. These probes provided high on/off signal ratios and exhibited good selectivity towards thiols over other analytes. Thus, they were identified as good sensors for the detection of thiols both in living cells and in rabbit plasma samples. |
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