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Novel branched isocyanides as useful building blocks in the Passerini-amine deprotection-acyl migration (PADAM) synthesis of potential HIV-1 protease inhibitors |
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| Authors: | David Gravestock Amanda L. Rousseau Anna C.U. Lourens Heinrich C. Hoppe Lindiwe A. Nkabinde Moira L. Bode |
| Affiliation: | 1. CSIR Biosciences, Private Bag X2, Modderfontein, Johannesburg 1645, South Africa;2. Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand, Private Bag 3, PO WITS 2050, South Africa |
| Abstract: | Novel branched isocyanides have been prepared from l-serine and used as building blocks in the Passerini-amine deprotection-acyl migration (PADAM) sequence for the preparation of compounds with activity against HIV-1 protease. |
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