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Chelation controlled reductive amination of cyclic ketones to trans-4-methoxycyclohexylamines: 9-BBN reduction mediated with FeCl3 |
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| Authors: | Bo Qu Nizar Haddad Sonia Rodriguez Heewon Lee Shengli Ma Xingzhong Zeng Diana C. Reeves Kanwar P.S. Sidhu Jon C. Lorenz Nelu Grinberg Carl A. Busacca Dhileepkumar Krishnamurthy Chris H. Senanayake |
| Affiliation: | Chemical Development US, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT 06877, USA |
| Abstract: | A novel trans-diastereoselective reductive amination of 4-substituted cyclohexanones is described using 9-BBN as reducing agent in the presence of FeCl3. The method permits efficient synthesis of structurally diverse 4-trans-alkoxycyclohexylamines. |
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