Chemical Development US, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT 06877, USA
Abstract:
A novel trans-diastereoselective reductive amination of 4-substituted cyclohexanones is described using 9-BBN as reducing agent in the presence of FeCl3. The method permits efficient synthesis of structurally diverse 4-trans-alkoxycyclohexylamines.