Acremolin,a new 1H-azirine metabolite from the marine-derived fungus Acremonium strictum |
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| Authors: | Elin Julianti Hana Oh Hyi-Seung Lee Dong-Chan Oh Ki-Bong Oh Jongheon Shin |
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| Institution: | 1. Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Republic of Korea;2. Marine Natural Products Laboratory, Korea Ocean Research & Development Institute, PO Box 29, Seoul 425-600, Republic of Korea;3. Department of Agricultural Biotechnology, College of Agriculture & Life Science, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-921, Republic of Korea |
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| Abstract: | Acremolin (1), a novel modified base, was isolated from the culture broth of the marine fungus Acremonium strictum. Based on combined spectroscopic analyses, the structure of this compound was that of a methyl guanine base containing an isoprene unit. In addition, the presence of a 1H-azirine moiety is unprecedented among natural products. This compound exhibited weak cytotoxicity against an A549 cell line. |
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