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Asymmetric α-hydroxy ketone synthesis by direct ketone oxidation using a bimetallic palladium(II) complex |
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| Authors: | Othman A Hamed Arab El-Qisairi Hanan Qaseer Emad M Hamed Patrick M Henry Daniel P Becker |
| Institution: | 1. Department of Chemistry, An-Njaha National University, PO Box 7, Nablus, Palestine;2. Department of Chemistry, Mu’tah University, PO Box 7, Mu’tah-Karak, Jordan;3. Department of Chemistry, University of Guelph, Ontario, Canada N1G 2W1;4. Department of Chemistry, Loyola University Chicago, 6525 N. Sheridan Road, Chicago, IL 60626, USA |
| Abstract: | The oxidation of ketones by a chiral bimetallic palladium(II) complex in the presence of CuCl2 in THF–water solvents gave an enantioselective synthesis of α-hydroxyketones in catalytic oxidation utilizing an atmosphere of oxygen. The ee’s ranged from 61% to 92%. The reaction was accelerated by addition of strong acid that presumably increases the rate of enolization. |
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