Synthesis of carbohydrate-functionalized thiophene-capped cyclopenta[c]thiophene for concanavalin A recognition |
| |
| Authors: | Soumyajit Das Santanu Mandal Balaram Mukhopadhyay Sanjio S Zade |
| |
| Institution: | Department of Chemical Sciences, Indian Institute of Science Education and Research, Kolkata, P.O. BCKV Campus Main Office, Mohanpur 741 252, Nadia, West Bengal, India |
| |
| Abstract: | Synthetic route to two different carbohydrate-functionalized oligothiophenes comprising central cyclopentac]thiophene (CPT) moiety was demonstrated. Turbidimetric analysis revealed enhanced interaction for divalent α-mannose-functionalized terthiophene 7 with Con A. The extent of binding interaction for 7-Con A complex formation was determined from isothermal titration calorimetry (ITC) measurements and the binding constant found (KITC) 2.4(6) × 105 M?1. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
