Synthesis of modified uracil and cytosine nucleobases using a microwave-assisted method |
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| Authors: | Laxmi Narayana Burgula K Radhakrishnan Lal Mohan Kundu |
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| Institution: | Department of Chemistry, Indian Institute of Technology Guwahati, North Guwahati, Assam 781039, India |
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| Abstract: | Modified nucleobases and nucleic acids have found many biological and pharmaceutical applications. Here we report a microwave-directed synthesis of a variety of modified uracil and cytosine nucleobases with high yields under solvent-free conditions. The reaction yields were further improved by addition of Lewis acid. The crystal structures of 5-isopropyl-6-methyluracil and 6-phenyluracil were also determined. |
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