Aqua mediated indium(III) chloride catalyzed synthesis of fused pyrimidines and pyrazoles |
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Authors: | Jitender M. Khurana Ankita Chaudhary Bhaskara Nand Anshika Lumb |
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Affiliation: | Department of Chemistry, University of Delhi, Delhi 110007, India |
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Abstract: | The utilization of water as solvent and indium trichloride as promoter for the three-component combinatorial synthesis of a variety of bioactive pyrimidine and pyrazole derivatives (2–10) from aldehydes, 1,3-dicarbonyl compounds, and electron-rich amino heterocycles like 6-amino-1,3-dimethyl uracil and 3-methyl-1-phenyl-1H-pyrazol-5-amine catalyzed by indium trichloride under reflux has been studied. A new class of pyrimidine derivatives (2) has also been synthesized and the structure was confirmed by single crystal X-ray analysis. The reactions are environmentally benign, reaction product could be isolated easily and the catalyst could be recycled, which makes it an appealing synthetic protocol. |
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