Aspergilazine A,a diketopiperazine dimer with a rare N-1 to C-6 linkage,from a marine-derived fungus Aspergillus taichungensis |
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| Authors: | Shengxin Cai Xianglan Kong Wei Wang Huinan Zhou Tianjiao Zhu Dehai Li Qianqun Gu |
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| Affiliation: | Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao, Shandong 266003, People’s Republic of China |
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| Abstract: | A novel diketopiperazine (DKP) dimer, aspergilazine A (1), dimerized by two DKP units via a rare N-1 to C-6 linkage, was isolated from the marine-derived fungus Aspergillus taichungensis ZHN-7-07. The structure was determined by the combination of spectroscopic and Marfey’s methods. Biological evaluation indicated that aspergilazine A (1) had a weak activity against influenza A (H1N1) virus. |
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