ortho-Induced transition-metal-free C-arylation cyclization reaction for the synthesis of polysubstituted isocoumarins |
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| Authors: | Lei Liu Jie Hu Xiang-Chuan Wang Mei-Jin Zhong Xue-Yuan Liu Shang-Dong Yang Yong-Min Liang |
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| Institution: | State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China |
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| Abstract: | A new protocol for the synthesis of polysubstituted isocoumarins from 2-iodobenzoic acid and β-diketone compounds has been developed. The occurrence of C-arylation cyclization reaction in transition-metal-free systems and ortho-induced substrates has been exploited. Reactions using these inexpensive conditions have displayed high functional group tolerance and excellent yields. |
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